Toon Boom Harmony 21 has been used in a wide range of applications, from television shows and films to commercials and video games. The software's versatility and flexibility have made it a favorite among studios and independent artists alike. For example, studios such as Warner Bros. Animation and DreamWorks Animation have relied on Harmony to produce hit shows like "Looney Tunes" and "How to Train Your Dragon." Independent artists have also leveraged the software to create innovative and critically acclaimed projects, such as music videos and short films.